Little Dixie Highway of the Great River Road

Getting to the Byway: St. Louis, MO Take I-70 west to St. Peters. Get on MO-79 and go north to Clarksville where the byway begins. Navigating the Byway: The byway begins on MO 79 at the Ralls-Pike county line 15 miles south of Hannibal. ##Ralls-Pike County Line to Clarksville (29 miles) * From the beginning of the byway, follow MO 79 to the town of Louisiana. * Once in Louisiana, turn east (left) onto US 54, then south (right) onto MO 79/ 3rd St. * Continue on MO 79 into Clarksville, where the Missouri section of the Great River Road ends at the intersection of MO 79 and Howard St.